Dr. Lobe is the headmaster of the titular school in the Big Brain Academy series. A yellow-y humanoid character, Dr. Lobe possesses a series of four whiskers that make up a moustache and wears rounded glasses. He is commonly seen with a pointer in hand and a graduation cap on his head. Dr. Lobe apparently lacks legs, as his primary mode of transportation comes in the form of a single-wheeled trolley.
Dr. Lobe appears as a stage boss on the 3DS stage Big Brain Academy in Super Smash Bros. Fusion. On the stage he will randomly appear and will, in a matter similar to the WarioWare stage from Brawl, activate a short minigame that will grant a prize upon completing it correctly. These minigames are based off the different challenges from Big Brain Academy.